The 60-year-old actress will star as Lieutenant Bishop in an all-new crime series from Dick Wolf, On Call.
Troian Bellisario leads the Prime Video series as "hard-charging but protective veteran officer Traci Harmon, who struggles to find her place in the department while training the next generation of officers," per a release.
Traci finds herself paired with "ambitious rookie" Alex Diaz (Brandon Larracuente), who "grapples with holding onto his optimistic outlook as he realizes the challenges he'll face in today's climate."
The "adrenalized and visceral police drama" sees Traci and Alex on patrol in Long Beach, Calif. and is told through a "mixture of bodycam, dash-camera, and cellphone footage to create a cinema verité effect" as a means of exploring "the morality of protecting and serving a community."
Along with Loughlin, Bellisario and Larracuente, Eriq La Salle stars as Sergeant Lasman and Rich Ting stars as Sergeant Koyama.
Loughlin's most recent role came in the final season of Curb Your Enthusiasm, as she played a heightened version of herself. However, in the sitcom, she was rejected from country clubs around Los Angeles due to her tarnished reputation following the college admissions scandal.
The legendary show's executive producer Jeff Schaffer later said that Loughlin was "totally game" to appear after hearing the pitch.
"This was an idea that we loved from a writer named Teddy Bressman. But it's not going to be funny with some sort of thinly veiled surrogate. It only works if we get Lori," Schaffer told The Hollywood Reporter after the March Curb episode aired. "So we called her manager up, who loved it, and who then talked to Lori, and she said: 'I'm in, I'm totally game.' And she was. She was so great."
"Everything we threw at her, she was game to do. She makes the episode. I'm so glad she wanted to do it."
Loughlin's upcoming role in the new Dick Wolf series comes after Felicity Huffman, who was also involved in the scandal, made her return to TV on Criminal Minds: Evolution this summer.
The role marked one of her first major roles since the scandal, for which she completed a sentence of jail time, community service and supervised release after pleading guilty to paying Rick Singer to have a proctor change her daughter's SAT answers.