The actress took to social media to celebrate her Friends co-star's milestone.
Jennifer Aniston has wished Courteney Cox a happy 60th birthday, saying it is one of the "great honours to call her one of my best friends for life".
Cox and Aniston rose to fame as Monica Geller and Rachel Green in the hit sitcom Friends.
In an Instagram post, Aniston shared images of her and Cox, including a clip from a scene on the show that made them household names, and a photo from a FaceTime call, blowing each other kisses.
Aniston, 55, who is also known for The Morning Show, wrote: "Celebrating this powerful, magical, mystical, interesting, interested, ferociously talented girl today!!! My sweet CC @courteneycoxofficial... she's funny like no other, stunning on the inside and out.
"Independent in the most gorgeous way, cares for everyone even if she doesn't know you.
"Terrified of dogs even though I've never known her not to have at least two of them. Fiercely loyal to the end.
"She'll redecorate a room like nobody's business. Spot a smudge on a window from a mile (literally) away. She doesn't care what other people think!! I can't imagine a world without her. It's one of my great honours to call her one of my best friends for life... Happy happy birthday CC. I love you!"
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Aniston is reportedly godmother to Cox's daughter Coco Arquette, whose father is Scream and Never Been Kissed actor David Arquette.
Cox, who has been with Snow Patrol's Johnny McDaid since 2013, was last year honoured with a star on the Hollywood Walk of Fame in LA with Aniston and Lisa Kudrow, who played Phoebe Buffay on Friends, also attending.
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